Brain In Vivo Transfection Kit

$590.00$8,750.00

Kit Size VolumePriceAdd to Cart
0.25 ml - 10 injections (Catalog #5090)$590.00
0.75 ml - 30 injections (Catalog #5091)$1,195.00
2.0 ml - 80 injections (Catalog #5092)$2,950.00
8.0 ml - 320 injections (Catalog #5093)$8,750.00
SKU: BRAINIV Category:

Description

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Brain In Vivo Transfection Reagent
Effectively delivers negatively charged biomolecules (DNA, RNA, small protein) into mouse/rat brain. Transfection kit for animal laboratory research (mouse, rat)

Modes of administration:

  • Systemic intravenous (i.v.) injection

Brain-targeted In Vivo Transfection Kit

  • Nanoparticle liposome-based reagent
  • IV systemic administration (tail vein)
  • Efficient delivery to the brain tissue and U87 orthotopic tumor
  • Efficient delivery of protein, small molecule, RNA, and pDNA into brain
  • Functionally validated in mice
  • Download Brain-targeted in vivo transfection protocol: [PDF] [Word]
  • Download safety data sheet: [PDF]
  • UPC/GTIN/EAN: 860002089719
  • Brand: ALTOGEN®, developed and manufactured by Altogen Biosystems

DATA

Figure 1. Systemic administration (i.v.) of Brain In Vivo Transfection Reagent conjugated with 150 ug of chemically modified siRNA targeting Lamin A/C mRNA or non-silencing control siRNA following the recommended protocol. Tissues (liver, brain, U87 orthotopic tumor, kidney, pancreas, heart, spleen, and lungs) were collected and RNA isolated 24 hours after first injection. Samples were analyzed by qRT-PCR for Lamin A/C gene expression levels. Ribosomal RNA levels were used to normalize the Lamin A/C data. Data are means ± SD (n=8).

Selected in vivo transfection reagents references:

  • PLoS Pathog. 2014 10(10) Exosomes from hepatitis C infected patients transmit HCV … Bukong et al [PDF]
  • Hypertension. 2012 59(1):158-66. Role of uncoupled endothelial nitric oxide synthase … Gao et al [PDF]
  • Jounal of Biological Chemistry. 2012 287(4):2907. Chaperoning of mutant p53 protein … Gogna et al [PDF]
  • J Proteome Res. 2012(11) Retinal proteome analysis in a mouse model of oxygen-induced … Kim et al [PDF]

Altogen Contract Research Services:

Altogen Labs provides biology CRO research services for IND applications and preclinical drug development. Please visit AltogenLabs.com

Volume Options:

  • 0.25 ml – 10 injections (Catalog #5090)
  • 0.75 ml – 30 injections (Catalog #5091)
  • 2.0 ml – 80 injections (Catalog #5092)
  • 8.0 ml – 320 injections (Catalog #5093)

Additional information

Weight1 lbs
Dimensions4 × 3 × 0.2 in
Kit Size (Volume)

0.25 ml – 10 injections (Catalog #5090), 0.75 ml – 30 injections (Catalog #5091), 2.0 ml – 80 injections (Catalog #5092), 8.0 ml – 320 injections (Catalog #5093)